Sam and Dean have to go a worldwide hunt for some magical artifact to save the world from getting destroyed by Lucifer, who wants to cleanse the world of all its sin. Castiel is the expert in whatever field they need to look into that they meet along the way. Cue some tomb raiding and Sam and Castiel doing most of the mental brain work while Dean does the tomb raiding?
Prompt, Team Castiel/Crowley, The Da Vinci Code